"Me and Mrs. Jones" is a 1972 soul song written by Kenny Gamble, Leon Huff and Cary Gilbert, and originally recorded by Billy Paul. It describes an extramarital affair between a man and his lover, Mrs. Jones. It has been covered by the 1970s group The Dramatics. Their version peaked at number 47 on the pop charts and number 4 on the R&B charts in 1974.

Other cover versions include Johnny Mathis (as the title song for the 1973 album Me and Mrs. Jones), the experimental rock band Sun City Girls (on the album Midnight Cowboys from Ipanema, 1986), Head (on the album A Snog on the Rocks, 1987), Sarah Jane Morris (on Sarah Jane Morris, 1989), Freddie Jackson (on Time for Love, 1992) Amii Stewart (on The Men I Love, 1995), Tower of Power (on the album Great American Soulbook, 2009), Andreas Weise (on Andreas Weise, 2012), Michael Bublé (his studio album, Call Me Irresponsible 2007) and covered live by Hall & Oates and Stevie Wonder.